In answer to Heather’s question of “did I have any defects from the pku”: There are negative side affects to living with untreated PKU. As a child I was very agitated, a lot of rage. As I got older my tremors and tics started getting worse, but are still subtle enough that others seldom notice them. There is irritability and headaches. My I.Q., however, is in the gifted range. My PKU symptoms are manageable and I am a very positive, happy person.