i recently attened a MPKU night at my clinic.. (maternal PKU) i was told that u should keep ur levels below 6 months prior to trying to concieve then throughout the pregnancy. i was also told once u become pregnat that u may need to have blood tests as much as 3 times a week. and u will have regular altrosounds and other testing.. they will keep a close eye on u and will beable to detect any troubles early on! hope that was of any help!!