It is important to begin treatment for PKU early in life by following a lifelong diet that is low in Phe (found mostly in foods high in protein). In addition to a low-Phe diet, some patients can benefit from a prescription medication that may help lower blood Phe levels, called KUVAN® (sapropterin dihydrochloride) Tablets for Oral Use or Powder for Oral Solution.
Treatment guidelines recommend maintaining Phe levels between 120-360 µmol/L (2-6 mg/dL) for life and suggest that all people with PKU, except those with two null mutations in trans, be offered a trial of KUVAN to determine if it can help lower blood Phe levels.1 Talk to your healthcare professional to find out if KUVAN is an option for you or your child.
Treatment for PKU includes:
Regular visits to a metabolic clinic are important for managing PKU. Find a metabolic clinic in your area.Read More
KUVAN® (sapropterin dihydrochloride) Tablets for Oral Use and Powder for Oral Solution are approved to reduce blood Phe levels in people with a certain type of Phenylketonuria (PKU). KUVAN is to be used with a Phe-restricted diet.
It is not possible to know if KUVAN will work for you without a trial of the medicine.
Your doctor will check your blood Phe levels when you start taking KUVAN to see if the medicine is working.
Starting KUVAN does not eliminate the need for ongoing dietary management. Any change to your diet may impact your blood Phe level. Follow your doctor’s instructions carefully. Your doctor and dietitian will continue to monitor your diet and blood Phe levels throughout your treatment with KUVAN to make sure your blood Phe levels are not too high or too low. If you have a fever, or if you are sick, your Phe level may go up. Tell your doctor and dietitian as soon as possible so they can make any necessary changes to your treatment.
Children younger than 7 years old treated with KUVAN doses of 20 mg/kg per day are at an increased risk for low levels of blood Phe compared with children 7 years and older. Frequent blood monitoring is recommended in this population to ensure that blood Phe levels do not fall too low.
Tell your doctor if you have ever had liver or kidney problems, have poor nutrition or have a loss of appetite, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.
KUVAN is a prescription medicine and should not be taken by people who are allergic to any of its ingredients. KUVAN and other medicines may interact with each other. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, herbal and dietary supplements.
If you forget to take your dose of KUVAN, take it as soon as you remember that day. Do not take 2 doses in a day. If you take too much KUVAN, call your doctor for advice.
The most common side effects reported when using KUVAN are headache, runny nose and nasal congestion, sore throat, diarrhea, vomiting, and cough. Additional adverse reactions reported in connection with worldwide marketing include sore throat, heartburn or pain in the esophagus, inflammation of the lining of the stomach, indigestion, stomach pain, and nausea. These are not all the possible side effects seen with KUVAN. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
KUVAN can cause serious side effects, including:
For more information, call BioMarin RareConnectionsTM at 1-877-MY-KUVAN (1-877-695-8826). Please read the full Patient Information by clicking here.
Reference: 1. Vockley J, Andersson HC, Antshel KM, et al; for the American College of Medical Genetics and Genomics Therapeutic Committee. Phenylalanine hydroxylase deficiency: diagnosis and management guideline. Genet Med. 2014;16(2):188-200.