I have been on a trial for Kuvan since mid-September. I have averaged a Phe level of 14.7 with readings in the mid-14 range, the mid-11 range and then 18.7 just before I began the trial. After being on Kuvan for 48 or 72 hours (I don't recall which is accurate) I had a Phe level of 8.5. A few days later I had a Phe level of 8.8. My last Phe level was 6.5. That was the lowest I ever remember having! When I was a child they would shoot for a Phe level of between 8-10. Now the normal range is considered 2-4. I believe I can accomplish this with Kuvan. My Nutritionist, Belkys, thinks this is a good goal for me and that with the Kuvan, and some minor diet adjustments, I may be able to hit that goal and maintain it. As a side note, I go to the lab weekly for now to get blood drawn for my Phe levels because I cannot do a finger stick. I prefer the needle in the arm and a 1 hour trip to my clinic. I know I am a bit odd. :)&gt;+ PKU has helped to make me who I am. Maybe I should not see it as an enemy, but as a challenge. Any parents of PKUers- I suggest you help them to see it as a challenge, not a disability.