So I started a Kuvan trial a few weeks ago. Part of the reason I waited so long to try it was because I kind of assumed I wouldn't be a responder. I am really sensitive to any slight changes in my diet. When I was a baby, my parents tried something called the "PKU challenge" which meant feeding me a high protein diet for 7 days to see what would happen. My levels shot up to 40 at that time. I sort of guessed that whatever enzyme was missing probably wasn't going to respond very well. I was pretty bummed out about it because I've definitely had my shares of ups and downs with this diet. I'm seriously y trying to be committed to this diet now, but I was really hoping I could be a little more relaxed with how I eat. I've heard so many people on here share how great it is. I know not everyone with PKU is on Kuvan....I guess it's time to get a little more creative with my low protein foods. Just thought I would share with you all because I'm grateful for everyone's support on here .